David Lacomis, MD

  • Professor of Neurology & Pathology

Education & Training

  • MD, Pennsylvania State University 1987

Representative Publications

Campellone JV, Lacomis D, Kramer DJ, Van Cott AC, Giuliani MJ.  Acute myopathy after liver transplantation.  Neurology 1998;50:46-53.

Lacomis D, Giuliani MJ, Van Cott A, Kramer DJ.  Acute myopathy of intensive care:  clinical, electromyographic, and pathological aspects.  Ann Neurol 1996;40:645-654.

Lacomis D, Petrella JT, Giuliani MJ.  Causes of neuromuscular weakness in the intensive care unit:  a study of 92 patients.  Muscle Nerve 1998;21:610-617.

Kao AH, Lacomis D, Lucas M, Fertig N, Oddis CV.  Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy.  Arth Rheum 2004;50:209-215.

Ranganathan S, Williams E, Ganchev P, Gopalakrishnan V, Lacomis D, Urbinelli L, Newhall K, Cudkowicz ME, Brown Jr RH, Bowser R.  Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis.  J  Neurochem 2005;95:1461-1471. PMID: 16313519

Lacomis D, Zivkovic SA.  Approach to vasculitic neuropathies.  J. Clin Neuromusc Dis 2007;9:265-276.

Ranganathan S, Georgina  CBN, Henry S, Lutka F, Sathanoori R, Lacomis D, Bowser R.  Comparative proteomic profiling of cerebrospinal fluid between living and postmortem ALS and control subjects.  Amyotrophic Lateral Sclerosis 2007;8:373-379. PMID: 17852009

Wang H, Larrieviere  KS, Keller KE, Ware KA, Burns TM, Conaway MA, Lacomis D, Pattee GL, Phillips LH, Solenski NJ, Zivkovic SA, Bennett JP. R(+) pramipexole as a mitochondrially focused neuroprotectant: Initial phase II studies in ALS. Amyotrophic Lateral Sclerosis 2007;9:50-58.

Abdel-Hamid H, Oddis CV, Lacomis D.  Severe hydroxychloroquine myopathy.  Muscle Nerve 2008; 38:1206-1210.

López de Padilla CM, Vallejo AN, Lacomis D, McNallan K, Reed AM.  Extra-nodal lymphoid microstructures in inflamed muscle and disease severity of new-onset juvenile dermatomyositis.  Arthritis Rheum 2009;60:1160-1172. PMID: 19333937

Bowser R, Lacomis D.  Applying proteomics to the diagnosis and treatment of ALS and related diseases.  Muscle Nerve, 2009;40:753-762. PMID: 19670321

Research Interests

Dr. Lacomis is the medical director of the Center for ALS Research. With Robert Bowser, PhD, he is studying ALS biomarkers in the cerebrospinal fluid and serum using mass spectrometry proteomics, and is site PI in a multicenter validation study. He is the site principal investigator in a Phase II trial of KNS-760704 (R+ pramipexole) and a phase III study of ceftriaxone in ALS.  He is an investigator in a pilot epidemiology study and in a study of non-invasive ventilation in ALS. He serves as a co-investigator in a large NIAMS-funded study using rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis.  Dr. Lacomis is the evaluator of muscle pathology specimens from all sites and serves on the Steering and Adjudication Committees.